Usage of compaction simulators for the powder compression characterization: Advantages and limitations

Compaction simulators are designed as machines which can provide an in-depth analysis of the powder compaction process. Characterization compression and process, well material characterization, play important role in formulation manufacturing process design development, creating a strong knowledge basis for scale-up tablet troubleshooting further stages product lifecycle. Although to simulate on high-speed tablet-presses, with advantages small quantity needed highly sophisticated instrumentation, there certain limitations extrapolation parameters from these rotary presses. However, advantage use studying basic mechanisms, identification critical attributes ranges, their relations characteristics quality pharmaceutical products is clear, compared excentre presses, complementary This scientific paper provides overview examples different provided by instrumentation simulators, including exploitation.